Local immunity features in patients with non-invasive muscular bladder cancer of various degrees of malignance

Purpose of the study . To features local distribution populations immune system cells in patients with non-invasive muscular bladder cancer various degrees malignancy. Materials and methods The included 51 newly diagnosed non-muscle-invasive (papillary urothelial carcinoma) who received complex treatment follow-up after 9 months at oncourological department National Medical Research Center Oncology. Patients were divided into two groups: group 1 – a tumor low malignant potential (Low grade LG), n = 31; 2 high (High HG), 20. After 6–9 months, 24 relapse disease 48,4 % ( 15) 45 9). In cell suspensions obtained from primary recurrent tumors, as well perifocal zone, relative number immunocompetent was estimated using flow cytometry. A comparison made content individual lymphocytes tissue, zone lesions Statistical processing performed Statistica 13.0. Results development is accompanied by involvement innate immunity (NK- NKT-lymphocytes) its microenvironment, which associated an imbalance main adaptive fairly pronounced decrease T-lymphocytes helper-inductor type noted constant cytotoxic T-lymphocytes, multidirectional nature changes DP- (decrease) DN-lymphocytes (increase). feature that it Conclusion Studies population composition tumors their tissues NMIBC revealed are reflected redistribution cytolytic cells, formation immunosuppressive conditions, both manifestation biological properties cellular involved process. progression cancer.